Weekly Spotlight
Illustration: Shoshana Gordon/Axios
Until now, most GLP-1 medications have only been available as injections. That has not stopped them from becoming some of the most effective treatments for weight loss and type 2 diabetes, but it has created a barrier for many people. Eli Lilly and Novo Nordisk are now getting closer to releasing GLP-1s in pill form. This could be a big step forward in making these medications easier to use and more widely available.
So what are the benefits of a pill over an injection? The biggest one is convenience. No needles, no storing pens in the fridge, no carrying around injection supplies. A pill is much easier to travel with and fits into most people’s daily routine without much thought. Pills may also be less intimidating for people who have avoided GLP-1s simply because they did not want to inject themselves.
There are also potential cost and access benefits. Manufacturing and shipping tablets is usually simpler and less expensive than injections. That could mean more consistent supply, lower costs, and better insurance coverage over time. And with multiple pill options in the pipeline, patients and doctors may have more flexibility in choosing the right medication and schedule.
There are still trade-offs to consider. In early studies, pills do not always match the full effectiveness of the strongest injectable GLP-1s. They may also come with more digestive side effects, and absorption can vary depending on timing, food, and the individual. These are details that the FDA will look at closely before approval.
Still, the arrival of a GLP-1 pill is exciting. It could make treatment less of a hurdle, reach people who were hesitant about injections, and expand access to a much larger group of patients. For many, this change could be the difference between considering GLP-1 medication and actually starting it.
For myself, I think it will be a useful ‘maintenance’ option that I can switch to once I’ve reached a desired target weight. Even though they may ultimately be less effective, for those of us that may not want to have to inject themselves for the rest of their lives, it presents a more simple method of continuing the medication.
Other News
GLP-1 drugs may reduce U.S. mortality by 6.4% as outlined by this news story.
As GLP-1s become more widely used there is some concern about teens and their exposure to people talking about the medication via social media.
Speaking of GLP-1 pills, Eli Lilly is hoping to get their version FDA approved by the end of the year.
Tips, Tricks & Side Effect Hacks
Tip: Know Your Injection Sites
Where you inject your GLP-1 medication can make a difference in comfort and absorption. Each site has its own pros and cons. I personally rotate on my belly button which has worked well for me.
Abdomen – Most common site; easy to access, often least painful. Some people notice mild redness or stinging. I’ve also seen it reported that some have experienced more nausea when injecting around their abdomen so trying the other sites may help.
Thigh – Convenient if you want to avoid the stomach. Injections here may absorb more slowly for some.
Upper Arm – Works well if someone else is helping you inject. Can be trickier to self-administer.
Rotation is key – Switching sites regularly helps prevent irritation, lumps, or scar tissue.
Personal preference matters – Try each location and see what feels most comfortable for you.
What I’ve Read / Watched / Listened to Lately
📄 Why Do We Lose Weight on GLP-1 Drugs?
A look at the mechanism on how GLP-1s work and why a certain study suggests something far more profound than simply eating less.
📺 Serena Williams on Why She Chose to Use GLP-1 Medication
Serena Williams discusses her GLP-1 journey and her hope to bring the conversation into the open and destigmatize the use of GLP-1 meds.
🎧 If GLP-1 Drugs are Good for Everything, Should We All Be on Them?
My first newsletter highlighted the article of the same name. This is the podcast version that includes additional commentary from 2 doctors on the effectiveness of GLP-1s.
Deals & Product Recs
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This Stanley AeroLight Transit Bottle is currently half off. I usually recommend the larger sizes but this looks good as a travel option.
Ensure Max Protein Cafe Mocha have been a go to for me in the morning. Usually mixed with an iced coffee.
I typically work from home and have been looking for easy ways to get some movement in while working and this Under Desk Elliptical has good reviews and is a Limited time deal.
Keeping it Light
Habanero Pepper Jelly
Another recipe coming from the backyard garden. This habanero pepper jelly can pack some heat so be careful! I’m going to try it with this smoked cream cheese and get real crazy.
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⚠️ Disclaimer
I am not a medical professional, and this information is provided for educational purposes only. It should not be taken as medical advice. If you are considering starting, stopping, or changing any GLP-1 medication, please consult with a licensed healthcare provider who can give you guidance based on your personal health history.